The effect of SKF 525A (2-diethylaminoethyl 2:2-diphenylvalerate hydrochloride) on organophosphate metabolism in insects and mammals.
نویسنده
چکیده
Lerman, S. (1959b). Nature, Lond., 184, 1406. Lerman, S. (1960a). A.M.A. Arch. Ophthal, 63, 128. Lerman, S. (1960b). A.M.A. Arch. Ophthal. (in the Press). Mitchell, H. S. & Dodge, W. M. (1935). J. Nutr. 9, 37. Pirie, A., van Heyningen, R. & Boag, J. W. (1953). Biochem. J. 54, 682. Strehler, B. L. & Totter, J. R. (1952). Arch. Biochem. Biophy8. 40, 28. van Heyningen, R. (1959). Biochem. J. 73, 197.
منابع مشابه
2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol.
When incubated with human liver microsomes, 2-diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) undergoes cytochrome P450 (P450)-dependent oxidative N-deethylation to the secondary amine metabolite 2-ethylaminoethyl-2,2-diphenylvalerate (SKF8742). P450-selective inhibitors indicated CYP3As catalyzed this reaction, and the deethylation rate correlated best with the CYP3A activity across a ran...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 79 شماره
صفحات -
تاریخ انتشار 1961